In 2007, humans became for the first time more urban than rural in our settlement patterns, and by the end of this century some two-thirds of people worldwide will be living in cities. This represents a noteworthy historical inflection point. Importantly, there are significant differences in the biophysical and psychosocial needs of people in urban areas at different stages of development. The intent of this collaborative workshop is to co-generate an integrally informed approach to urban planning, design, and management. Following a brief context-setting introduction, participants will self-organize into the 4 Quadrants and co-generate goals and strategies that address the physical infrastructure (UR), socio-ecological systems (LR), psychological experience (UL), and cultural meaning (LL) of cities and districts in different developmental contexts. In so doing, this workshop aims to generate a conceptual foundation to improve the livability and sustainability of urban habitats worldwide where the vast majority of people will soon live, work, and play.