Novel research explored how two essential aspects of human experience relate to each other: (a) one’s stage of psychosocial maturity (operationalized through integral ego development stages), and (b) one’s conception and experience of meaning in their life. The study suggests that adults at postconventional stages of ego development experience and conceive of meaning-in-life in a qualitatively different way than those at earlier stages and, importantly, in a way that conflicts with the dominant psychological models and measures of meaning-in-life. Meaning for post-conventional adults contradicts or transcends the purpose, significance, and coherence requirements inherent in contemporary psychological scholarship on meaning-in-life. These results not only suggest the need for adjustment to existing meaning-in-life models, but also suggest that research and practice regarding all psychological phenomena (e.g., happiness, gender identity) should consider the effects of developmental diversity. An additional byproduct of the research is insight into the meaning-making of individuals at later stages of the integral ego development spectrum.